Xenograft Antitumor Assay is a laboratory technique used in cancer research to evaluate the effectiveness of potential drugs or treatments in inhibiting the growth of tumors.
The term "xenograft" refers to the process of transplanting living cells, tissues, or organs from one species to another. In the case of a Xenograft Antitumor Assay, tumor fragments or cells from a donor organism, often a human, are transplanted into an animal model, typically mice. This enables researchers to study the behavior and response of the transplanted tumor in a controlled environment.
The purpose of this assay is to measure and assess the antitumor activity of a specific treatment or drug candidate. This is typically done by administering the experimental drug to the animal model, either orally, intravenously, or by injection, and then monitoring the progression or regression of the transplanted tumor.
The response of the tumor to the treatment can be analyzed through various measurements and observations such as tumor growth rate, tumor volume, tumor weight, or the presence of metastasis. These findings provide valuable insights into the potential effectiveness of the treatment in inhibiting tumor growth or spreading.
Overall, the Xenograft Antitumor Assay is a critical tool used in preclinical testing of potential cancer therapeutics, enabling researchers to evaluate and compare the antitumor efficacy of different treatments and guide their development towards clinical trials.
