WHOLE COMPLEMENT TITER Meaning and
Definition
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Whole complement titer, also known as total complement titer or total hemolytic complement titer, is a measure of the activity or concentration of the complement system in a biological sample, such as blood serum. The complement system is an integral part of the immune system that helps in the defense against invading microorganisms and the removal of damaged cells. It consists of a group of plasma proteins that interact in a cascading manner to facilitate various immune responses.
The whole complement titer is determined by a series of laboratory tests that assess the ability of the complement system to lyse or destroy target cells, typically red blood cells. This titer provides information about the overall function and activity of the complement system, reflecting the presence and functionality of all the complement components involved in the cascade.
A higher whole complement titer indicates a greater concentration and activity of the complement system in the sample, suggesting an enhanced ability to combat infections and other pathological conditions. Conversely, a lower complement titer can indicate a deficiency or dysfunction in the complement system, which may predispose individuals to certain infections or autoimmune disorders.
The whole complement titer is an important diagnostic tool used in the assessment of complement-mediated diseases and to monitor the effectiveness of treatment strategies targeting the complement system. By measuring the activity and concentration of the complement system, healthcare professionals can gain valuable insights into the immune status and overall health of individuals.
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