OPEN READING FRAMES Meaning and
Definition
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Open Reading Frames (ORFs) are sections of a DNA or RNA sequence that potentially encode functional proteins. ORFs are identified by examining the nucleotide sequence and detecting regions of DNA or RNA that begin with a start codon (usually AUG) followed by a series of codons that do not include any stop codons (UAA, UAG, or UGA) until a stop codon is encountered.
Typically, an ORF starts with a start codon and ends at the first in-frame stop codon encountered. While not all ORFs encode functional proteins, their identification is important as they provide potential genetic information. To determine the functional potential of an ORF, bioinformatic tools and computational algorithms are commonly employed to analyze the sequence for characteristics such as similarity to known proteins, presence of conserved domains, and presence of signal peptides.
Since DNA is composed of three nucleotides per codon, an ORF must be divisible by three to maintain the reading frame and ensure the correct amino acid sequence is translated. ORFs can be found in all organisms, and the identification and analysis of ORFs play a vital role in the study of genomics, proteomics, and functional genomics as it helps in characterizing genes, gene prediction, and understanding the structure and function of proteins encoded by those genes.
Common Misspellings for OPEN READING FRAMES
- ipen reading frames
- kpen reading frames
- lpen reading frames
- ppen reading frames
- 0pen reading frames
- 9pen reading frames
- ooen reading frames
- olen reading frames
- o-en reading frames
- o0en reading frames
- opwn reading frames
- opsn reading frames
- opdn reading frames
- oprn reading frames
- op4n reading frames
- op3n reading frames
- opeb reading frames
- opem reading frames
- opej reading frames
- opeh reading frames
