HLA DR ANTIGEN Meaning and
Definition
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HLA DR antigen refers to a specific type of human leukocyte antigen (HLA) molecule known as HLA-DR. HLAs are genetically inherited proteins that are present on the surface of almost all nucleated cells in the human body. They play a crucial role in immune system function by helping the body distinguish between self and non-self cells, thus enabling the immune system to target and eliminate foreign substances or pathogens.
HLA-DR antigens are classified as major histocompatibility complex (MHC) class II molecules. They are composed of two chains, an alpha chain (encoded by HLA-DRA genes) and a beta chain (encoded by HLA-DRB genes). The HLA-DR antigen is primarily expressed on antigen-presenting cells, especially B cells, macrophages, and dendritic cells. HLA-DR molecules play a critical role in antigen presentation to helper T cells, essential for the activation of the adaptive immune response.
HLA-DR antigens exhibit a high degree of polymorphism, meaning they exist in multiple allelic forms, which vary among individuals. This genetic variation is a result of different combinations of specific HLA-DR alleles inherited from each parent. The diversity in HLA-DR antigens allows the immune system to recognize a wide range of foreign substances and mount a robust immune response against various pathogens.
The typing and characterization of HLA-DR antigens are important in clinical settings such as organ transplantation, as mismatched HLA-DR antigens can lead to rejection of transplanted tissues. Additionally, HLA-DR antigens have been implicated in various autoimmune diseases, wherein the immune system mistakenly targets the body's own cells and tissues.
Common Misspellings for HLA DR ANTIGEN
- gla dr antigen
- bla dr antigen
- nla dr antigen
- jla dr antigen
- ula dr antigen
- yla dr antigen
- hka dr antigen
- hpa dr antigen
- hoa dr antigen
- hlz dr antigen
- hls dr antigen
- hlw dr antigen
- hlq dr antigen
- hla sr antigen
- hla xr antigen
- hla cr antigen
- hla fr antigen
- hla rr antigen
- hla er antigen
- hla de antigen
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