GLU TRNA LIGASE Meaning and
Definition
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Glu tRNA ligase, also known as glutamyl-tRNA synthetase, is an enzyme that plays a crucial role in protein synthesis. It is classified as a ligase since it catalyzes the formation of a covalent bond between glutamate amino acid and its corresponding transfer RNA (tRNA), resulting in the attachment of glutamate to the 3' end of tRNA.
The process of protein synthesis requires accurate and specific attachment of amino acids to their respective tRNAs by aminoacyl-tRNA synthetases. Glu tRNA ligase specifically recognizes and binds to the amino acid glutamate, and also recognizes the specific tRNA that carries glutamate (tRNA(Glu)). This enzyme then facilitates the transfer of glutamate from its activated form, glutamate adenylate, to the tRNA molecule.
The formation of the aminoacyl-tRNA complex is vital for further steps in protein synthesis, as the tRNA molecule acts as the adapter between the mRNA codons and the corresponding amino acids. This ensures that the correct amino acid is incorporated into the growing polypeptide chain during translation.
Mutations or dysfunction in the gene encoding Glu tRNA ligase can lead to various disorders known as aminoacyl-tRNA synthetase deficiencies, which can manifest as neurologic, muscular, or systemic diseases. Therefore, Glu tRNA ligase is a critical enzyme in maintaining proper protein synthesis and cellular function.
Common Misspellings for GLU TRNA LIGASE
- flu trna ligase
- vlu trna ligase
- blu trna ligase
- hlu trna ligase
- ylu trna ligase
- tlu trna ligase
- gku trna ligase
- gpu trna ligase
- gou trna ligase
- gly trna ligase
- glh trna ligase
- glj trna ligase
- gli trna ligase
- gl8 trna ligase
- gl7 trna ligase
- glu rrna ligase
- glu frna ligase
- glu grna ligase
- glu yrna ligase
- glu 6rna ligase
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