FOLYL POLYGLUTAMATE CLEAVAGE ENZYME Meaning and
Definition
-
Folyl Polyglutamate Cleavage Enzyme refers to a group of enzymes that are involved in the metabolism of folate, a B-vitamin essential for various cellular processes. These enzymes play a crucial role in breaking down polyglutamate forms of folate into monoglutamate, which is the active form of folate utilized by cells.
The enzyme acts by cleaving the polyglutamate tail attached to folate molecules. Polyglutamate forms of folate are less biologically active and are typically found in dietary sources or in the liver as a storage form. Before folate can be effectively transported into cells or utilized by enzymes in cellular metabolic pathways, it needs to be converted into monoglutamate.
Folyl Polyglutamate Cleavage Enzyme, also known as γ-glutamyl hydrolase, performs this catalytic function. It hydrolyzes the peptide bond between the gamma-glutamyl residue and the folate molecule, thereby releasing individual glutamate units. The cleavage of the polyglutamate tail allows for better absorption of folate in the intestine and its subsequent utilization in cellular processes such as DNA synthesis, methylation reactions, and the production of red blood cells.
Deficiencies or abnormalities in this enzyme can lead to impaired folate metabolism and result in a variety of health issues, including megaloblastic anemia, neural tube defects, and an increased risk of certain cancers. Understanding the role and function of Folyl Polyglutamate Cleavage Enzyme is essential for assessing folate metabolism and developing strategies to optimize folate utilization for maintaining overall health and preventing related disorders.
Common Misspellings for FOLYL POLYGLUTAMATE CLEAVAGE ENZYME
- dolyl polyglutamate cleavage enzyme
- colyl polyglutamate cleavage enzyme
- volyl polyglutamate cleavage enzyme
- golyl polyglutamate cleavage enzyme
- tolyl polyglutamate cleavage enzyme
- rolyl polyglutamate cleavage enzyme
- filyl polyglutamate cleavage enzyme
- fklyl polyglutamate cleavage enzyme
- fllyl polyglutamate cleavage enzyme
- fplyl polyglutamate cleavage enzyme
- f0lyl polyglutamate cleavage enzyme
- f9lyl polyglutamate cleavage enzyme
- fokyl polyglutamate cleavage enzyme
- fopyl polyglutamate cleavage enzyme
- fooyl polyglutamate cleavage enzyme
- foltl polyglutamate cleavage enzyme
- folgl polyglutamate cleavage enzyme
- folhl polyglutamate cleavage enzyme
- folul polyglutamate cleavage enzyme
- fol7l polyglutamate cleavage enzyme
Infographic
Add the infographic to your website:
