CANCER PATHOGENESIS Meaning and
Definition
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Cancer pathogenesis refers to the biological process by which normal cells within the body undergo transformation and develop into cancer cells. It involves understanding the series of events, changes, and mechanisms that lead to the formation and progression of cancer.
In cancer pathogenesis, healthy cells acquire genetic mutations or epigenetic alterations that disrupt their normal growth control mechanisms and render them susceptible to uncontrolled cellular proliferation. These alterations can be caused by various factors, including exposure to carcinogens, genetic predisposition, or aging.
The pathogenesis of cancer typically involves multiple stages. Initiation is the initial step where a genetic alteration occurs, potentially due to the influence of DNA-damaging agents or defects in mechanisms that maintain genomic stability. This leads to the creation of a mutated cell, which may not necessarily lead to cancer development.
Subsequently, during the promotion stage, the mutated cells are stimulated to proliferate and accumulate. Factors such as hormones, inflammation, and growth factors contribute to this stage, promoting the proliferation of these altered cells.
The final critical step in cancer pathogenesis is progression, during which the accumulated genetic alterations confer additional advantages to the mutated cells, allowing them to proliferate aggressively, invade surrounding tissues, and eventually metastasize to distant body parts.
The study of cancer pathogenesis enables scientists and researchers to elucidate the complex mechanisms behind cancer development and progression, leading to the identification of novel therapeutic targets and the development of more effective treatments.
Common Misspellings for CANCER PATHOGENESIS
- xancer pathogenesis
- vancer pathogenesis
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Etymology of CANCER PATHOGENESIS
The term "cancer" originates from the Latin word "cancer", meaning crab. This usage is attributed to the resemblance of a tumor to a crab, with its spreading limbs. The word "pathogenesis" originates from the Greek words "pathos", meaning suffering or disease, and "genesis", meaning origin or development. Thus, the etymology of "cancer pathogenesis" can be understood as the development or origin of disease within the context of cancer.
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