ANTIBODY DIRECTED ENZYME PRODRUG THERAPY Meaning and
Definition
-
Antibody directed enzyme prodrug therapy (ADEPT) is a targeted cancer therapy that involves the use of specially engineered molecules to selectively deliver therapeutic agents to cancer cells, while minimizing damage to healthy cells. This approach combines the high specificity of antibodies with the cytotoxic potential of enzymes and prodrugs.
ADEPT involves three main components: an antibody, an enzyme, and a prodrug. The antibody, usually a monoclonal antibody, is designed to bind specifically to a cell surface receptor or antigen that is overexpressed on cancer cells. The enzyme, known as a prodrug-activating enzyme, is attached to the antibody or delivered separately. The prodrug is a biologically inactive compound that is converted into its active form by the enzymatic activity of the prodrug-activating enzyme.
Once the antibody-enzyme complex binds to cancer cells, the prodrug is administered. The prodrug is specifically designed to be activated by the enzyme, resulting in the generation of a cytotoxic compound that selectively kills the cancer cells. This localized activation of the prodrug within the tumor microenvironment enhances the therapeutic efficacy while minimizing toxicity to healthy cells and tissues.
ADEPT offers several advantages over conventional chemotherapy. It allows more specific targeting of cancer cells, which reduces the side effects associated with systemic chemotherapy. It also enhances the therapeutic efficacy by increasing the concentration of the cytotoxic compound at the tumor site. Additionally, ADEPT has the potential for personalized medicine, as the choice of antibody, enzyme, and prodrug can be tailored to the individual patient's cancer characteristics.
Common Misspellings for ANTIBODY DIRECTED ENZYME PRODRUG THERAPY
- zntibody directed enzyme prodrug therapy
- sntibody directed enzyme prodrug therapy
- wntibody directed enzyme prodrug therapy
- qntibody directed enzyme prodrug therapy
- abtibody directed enzyme prodrug therapy
- amtibody directed enzyme prodrug therapy
- ajtibody directed enzyme prodrug therapy
- ahtibody directed enzyme prodrug therapy
- anribody directed enzyme prodrug therapy
- anfibody directed enzyme prodrug therapy
- angibody directed enzyme prodrug therapy
- anyibody directed enzyme prodrug therapy
- an6ibody directed enzyme prodrug therapy
- an5ibody directed enzyme prodrug therapy
- antubody directed enzyme prodrug therapy
- antjbody directed enzyme prodrug therapy
- antkbody directed enzyme prodrug therapy
- antobody directed enzyme prodrug therapy
- ant9body directed enzyme prodrug therapy
- ant8body directed enzyme prodrug therapy
Infographic
Add the infographic to your website:
