How Do You Spell ABELSON MURINE LEUKEMIA VIRUS?

1. Abelson murine leukemia virus (Ab-MLV) is a retrovirus that infects and causes leukemia in certain strains of mice. It belongs to the gammaretrovirus genus of the Retroviridae family and is commonly used in laboratory research as a model to study various aspects of cancer biology.

   Ab-MLV was named after its discoverer, Howard M. Temin, who isolated the virus in 1970 from a mouse sarcoma. The virus is relatively simple in structure, consisting of a single-stranded RNA genome enclosed within an envelope derived from the host cell membrane.

   Ab-MLV primarily infects hematopoietic cells, particularly B-cell precursors, and can induce the transformation of these cells into cancerous forms. It achieves this by integrating its viral DNA into the host cell genome, thereby altering the normal functioning of cellular genes involved in growth regulation, apoptosis, and differentiation. The infected cells undergo uncontrolled proliferation, leading to the development of leukemia.

   Besides its role as a pathogenic agent, Ab-MLV is also commonly used as a vector in gene transfer experiments due to its ability to efficiently deliver genetic material into target cells. It has been widely employed for the introduction and expression of specific genes in various cell types, aiding the elucidation of gene function and the development of gene therapy strategies.

   Overall, Abelson murine leukemia virus is recognized for its significant contribution to understanding the molecular mechanisms of cancer development and as a valuable tool in experimental research.

Common Misspellings for ABELSON MURINE LEUKEMIA VIRUS

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